Patent · US Active

Pyrazolopyridine derivatives and uses thereof

US12252482B2 · kind B2 · utility

0Cited by

3References

22Claims

0Family size

Assignee

Novartis AG · CH

Inventors

Simone BONAZZI · Cambridge, US
Jennifer Stroka Cobb · Stow, US
Natalie Dales · Arlington, US
Matthew James HESSE · Oakland, US
Rama Jain · Danville, US
John Ryan Kerrigan · Wakefield, US
Hasnain Ahmed Malik · Boston, US
James R. MANNING · Pleasant Hill, US
Pamela YF TING · Somerville, US

Key dates

Filing date	Sep 6, 2024
Grant date	Mar 18, 2025
Priority date	—
Expiry date	Sep 17, 2044

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.