Dominant salt forms of pyrimidine derivatives, and crystal forms thereof

US12252487B2 · kind B2 · utility

Assignee

• GUANGDONG RAYNOVENT BIOTECH CO., LTD. · CN

Inventors

• Xiaoxin Chen · Cupertino, US
• Chengwu Liu · 流花街道, CN
• Zhuowei Liu · 流花街道, CN
• Zhenyou Tan · 流花街道, CN
• Zhiqiang Liu · Kyoto, JP
• Zhiwei Cheng · 流花街道, CN
• Chaofeng Long · Tangxia, CN
• Jiajun Huang · Longbeilingcun, CN
• Guangqiang Zhou · 流花街道, CN

Key dates

• Filing date: Jun 24, 2020
• Grant date: Mar 18, 2025
• Expiry date: May 23, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are sodium salts of pyrimidine derivatives, and a series of crystal forms thereof. The series of crystal forms exhibit a good druggability, such as stability, fluidity, compressibility, etc., and provide a variety of options of APIs for subsequent drug product development.