Mutated polypeptides, compositions comprising the same, and uses thereof
US12252512B2 · kind B2 · utility
0Cited by
19References
33Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 25, 2023 |
| Grant date | Mar 18, 2025 |
| Priority date | — |
| Expiry date | Jul 25, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/20222
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided for herein are viral particles comprising a heterologous viral glycoprotein and a targeting moiety, wherein the targeting moiety comprises a polypeptide comprising a formula of T-S1, wherein T is a target binding domain and S1 is a stalk portion. The stalk portion may comprise a variant Fe domain. The stalk portion may comprise a flexible polypeptide domain. The targeting moiety comprising the formula T-S1 may be incorporated into a viral particle to assist with targeting such particles to a specific cell type. Also provided for herein are compositions comprising the same, and methods of using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.