Myosin 15 promoters and uses thereof

US12252520B2 · kind B2 · utility

Assignees

• Decibel Therapeutics, Inc. · US
• REGENERON PHARMACEUTICALS, INC. · US

Inventors

• Joseph BURNS · Newton, US
• Kathryn ELLIS · Arlington, US
• Adam PALERMO · Boston, US
• Martin SCHWANDER · Riverview, US
• Jonathon WHITTON · Cambridge, US
• Leah Sabin · Goldens Bridge, US
• Christos Kyratsous · Dobbs Ferry, US
• Meghan Drummond Samuelson · Tarrytown, US

Key dates

• Filing date: Aug 6, 2021
• Grant date: Mar 18, 2025
• Expiry date: Nov 24, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides polynucleotides containing regions of the Myosin 15 (Myo15) promoter, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in hair cells. The polynucleotides described herein may be operably linked to a transgene, such as a transgene encoding a therapeutic protein, so as to promote hair cell-specific expression of the transgene. The polynucleotides described herein may be operably linked to a therapeutic transgene and used for the treatment of subjects having or at risk of developing hearing loss or vestibular dysfunction.