Method of preparing a hydrogel product

US12252594B2 · kind B2 · utility

Assignee

• Galderma Holding SA · CH

Inventors

• Lars Nord · Lund, SE
• Hotan MOJARRADI · Uppsala, SE
• Johan Olsson · Bromma, SE

Key dates

• Filing date: Dec 27, 2019
• Grant date: Mar 18, 2025
• Expiry date: Sep 14, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08K5/1545
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, comprising the steps of: (a) providing a mixed solution of glycosaminoglycan molecules, a di- or multinucleophilic functional crosslinker, and a mononucleophilic functional graft chain; (b) activating carboxyl groups on the glycosaminoglycan molecules with a coupling agent to form activated glycosaminoglycan molecules; and (c) simultaneously crosslinking the activated glycosaminoglycan molecules and grafting the graft chain to the activated glycosaminoglycan molecules by reacting the nucleophiles with the activated carboxyl groups.