RNA-guided nucleases and active fragments and variants thereof and methods of use
US12252706B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 2024 |
| Grant date | Mar 18, 2025 |
| Priority date | — |
| Expiry date | Apr 29, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2521/301
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease (RGN) polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are RGN systems for binding a target sequence of interest, wherein the RGN system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.