Preparation method and application of water-soluble chlorhexidine hyaluronate antibacterial agents
US12256737B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 2024 |
| Grant date | Mar 25, 2025 |
| Priority date | — |
| Expiry date | May 13, 2044 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01P1/00
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
Disclosed are a water-soluble chlorhexidine antimicrobial agent and a preparation method therefor and use thereof. The present disclosure takes hyaluronic acid as a raw material to prepare a hyaluronic acid aqueous solution or organic solution, then the hyaluronic acid aqueous solution or organic solution and a chlorhexidine solution are subjected to a complexation reaction, an insoluble substance therein is removed, and then the resulting solution is dried to obtain the water-soluble chlorhexidine antimicrobial agent, namely hyaluronic acid chlorhexidine. The hyaluronic acid chlorhexidine has a good broad-spectrum antimicrobial performance, and excellent water solubility. The hyaluronic acid chlorhexidine combines advantages of hyaluronic acid and chlorhexidine, has good biocompatibility, no cytotoxicity, no skin irritation, and good moisture retention, can be prepared into an antimicrobial aqueous solution or gel, ointment and other products, and is used in the fields of medical devices, skin wound nursing, oral nursing, personal hygiene, environmental disinfection and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.