Vaccine compositions having improved stability and immunogenicity

US12257297B2 · kind B2 · utility

Inventors

• Gale Smith · Germantown, US
• Ye Liu · Foster City, US
• Jing-Hui Tian · Germantown, US
• Michael J. MASSARE · Mount Airy, US
• Sarathi BODDAPATI · Germantown, US
• Erica Shane · McLean, US
• Cynthia N. Oliver · Potomac, US
• Gregory M. Glenn · Bethesda, US

Key dates

• Filing date: May 23, 2022
• Grant date: Mar 25, 2025
• Expiry date: Jul 23, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/18534
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.