Nanostructured active ingredient carrier system

US12257316B2 · kind B2 · utility

Assignee

• Friedrich-Schiller-Universitat Jena · DE

Inventors

• Anja Traeger · Trebgast, DE
• Anne-Kristin Truetzschler · Jena, DE
• Tanja Bus · Jena, DE
• Ulrich Schubert · Jena, DE

Key dates

• Filing date: Jul 1, 2022
• Grant date: Mar 25, 2025
• Expiry date: Oct 9, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a nanostructured active ingredient carrier system, in particular for reducing cytotoxic properties owing to the use of sheath polymer and the transport resulting therefrom, for interactions with cell membranes during the transport of hydrophilic constituents and, in connection therewith, the generation of an early endosomal release of the interaction complex from the carrier system. The problem addressed by the present invention is that of specifying a nanostructured active ingredient carrier system which avoids the disadvantages of the prior art and in particular permits a reduction in cytotoxic properties owing to the use of a sheath polymer and the transport resulting therefrom. This problem is solved in that a nanostructured active ingredient carrier system is provided in the form of a particle consisting of a carrier sheath, wherein the carrier sheath comprises at least one or more hydrophobic sheath polymers, one or more charged complexing polymers and one or more hydrophilic active ingredients, wherein the complexing polymer interacts with the active ingredient.