Polynucleotide compositions, related formulations, and methods of use thereof
US12257318B2 · kind B2 · utility
0Cited by
8References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 2, 2024 |
| Grant date | Mar 25, 2025 |
| Priority date | — |
| Expiry date | Feb 2, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions of polynucleotide(s), pharmaceutical compositions thereof, and methods of use thereof are disclosed. A polynucleotide may encode for a cystic fibrosis transmembrane conductance regulator (CFTR) protein or a functional fragment thereof. The polynucleotide may be assembled with a lipid composition for targeted delivery to a cell or an organ, such as a lung cell or a lung of a subject. Methods for enhancing an expression or activity of CFTR protein in a cell are provided. Methods for treating a subject having or suspected of having a CFTR-associated condition are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.