Adenovirus armed with bispecific T cell engager
US12258417B2 · kind B2 · utility
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17References
23Claims
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Key dates
| Filing date | Aug 29, 2017 |
| Grant date | Mar 25, 2025 |
| Priority date | — |
| Expiry date | Feb 21, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engagers each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.