Modified oligonucleotides

US12258563B2 · kind B2 · utility

Assignee

• EMPIRICO INC. · US

Inventors

• Darren H. Wakefield · Fitchburg, US
• Lauren J. Almeida · Madison, US
• David B. Rozema · Madison, US
• Omri GOTTESMAN · Sierra Sky Park, US
• David L. Lewis · Madison, US

Key dates

• Filing date: Mar 27, 2023
• Grant date: Mar 25, 2025
• Expiry date: Apr 14, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3515
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions comprising modified oligonucleotides. In some embodiments, the oligonucleotide includes a hydrophobic moiety. In some embodiments, the oligonucleotide includes a vinyl phosphonate. In some embodiments, the oligonucleotide includes modified oligonucleotide sugars such as 2′ modified ribose molecules. In some embodiments, the oligonucleotide includes modified internucleoside linkages such as phosphorothioate linkages. In some embodiments, the oligonucleotide includes an siRNA. In some embodiments, the siRNA comprises a duplex region with overhangs on either end.