Dynamic clamps and methods of use thereof
US12259378B2 · kind B2 · utility
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7Claims
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Assignee
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Key dates
| Filing date | May 28, 2019 |
| Grant date | Mar 25, 2025 |
| Priority date | — |
| Expiry date | Jul 27, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/705
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for determining the phenotype (e.g., gain-of-function or loss-of-function) of a mutation in an ion channel or receptor by using a dynamic voltage clamp. The invention also features methods of determining whether a mutation is a gain-of-function or loss-of-function mutation and treating a disease or disorder associated with the particular gain-of-function or loss-of-function mutation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.