Limit of detection based quality control metric
US12260935B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Jun 2, 2020 |
| Grant date | Mar 25, 2025 |
| Priority date | — |
| Expiry date | Jun 6, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/30
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Provided are methods and systems for sample quality control in CNV detection using test samples comprising cell-free nucleic acid fragments originating from a mother and a fetus. The method involves determining an exclusion region defined by at least a fetal fraction limit of detection (LOD) curve. The fetal fraction LOD curve varies with coverage values and indicates minimum values of fetal fractions needed to achieve a detection criterion given different coverages.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.