Method of introducing an mRNA molecule into a cell
US12263182B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 24, 2019 |
| Grant date | Apr 1, 2025 |
| Priority date | — |
| Expiry date | May 19, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C13/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention concerns an in vivo method for introducing an mRNA molecule (which is not associated with a carrier) into the cytosol of a cell(s) in a subject, by the use of photochemical internalization, wherein the photosensitising agent is a sulphonated meso-tetraphenyl chlorin, sulfonated tetraphenylporphine or a di- or tetrasulfonated aluminium phthalocyanine used in an amount of 0.0001 to 1 μg. The method may be used to express a polypeptide in the subject. The invention is also directed to pharmaceutical compositions containing the photosensitising agents and the mRNA and uses of the molecules in therapy, e.g. to treat or prevent cancer or an infection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.