Therapeutic composition and method combining multiplex immunotherapy with cancer vaccine for the treatment of cancer
US12263219B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 11, 2022 |
| Grant date | Apr 1, 2025 |
| Priority date | — |
| Expiry date | Feb 11, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55522
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to a therapeutic composition comprising i) at least two immune checkpoint inhibitors, ii) at least one drug selected from a cytokine a cytotoxic or cytostatic chemotherapeutic drug, and combinations thereof, and iii) a cancer vaccine prepared from tumor or cancer cells, or derivatives thereof, that have been prepared through an ex vivo treatment that creates necrotic and/or necroptotic cancer cells while minimizing destruction of cancer antigens. This invention also relates to a method of treating a tumor or a cancer in a patient comprising administering to a patient in need thereof the therapeutic composition in an amount effective to treat the tumor or cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.