Rho kinase inhibitor, method for preparing same and uses thereof

US12264146B2 · kind B2 · utility

Assignee

• Beijing Increase Innovative Drug Co., LTD · CN

Inventors

• Baoxian Zhang · Beijing, CN
• Hongwu Zhang · Beijing, CN
• Jie Hu · Tangxia, CN
• Zhiyun Kang · Beijing, CN
• Chunmei XUE · Beijing, CN
• Wenhui Li · Nanhu, CN
• Yanwei Song · Beijing, CN
• Zhenzhen WU · Beijing, CN
• Anping Chen · Beijing, CN
• Fang Wang · Changzhou City, CN
• Hengchun Ren · Beijing, CN
• Jun Li · Ningbo City, CN

Key dates

• Filing date: May 6, 2019
• Grant date: Apr 1, 2025
• Expiry date: Jan 17, 2042

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer.