Patent · US Active

Compositions and methods for capping RNAS

US12264175B2 · kind B2 · utility

0Cited by

90References

6Claims

0Family size

Assignee

VERVE THERAPEUTICS, INC. · US

Inventors

Christopher Cheng · Cambridge, US
Kallanthottathil G. Rajeev · Wayland, US
Caroline Reiss · Cambridge, US

Key dates

Filing date	Mar 1, 2023
Grant date	Apr 1, 2025
Priority date	—
Expiry date	Mar 1, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/20
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are compositions and methods for preparation of 5′ end region-modified mRNAs. In particular, the instant disclosure relates to novel mRNA 5′ end region motifs and sequence initiators therefore together with assays that are capable of measuring the aspects of the functionality of those motifs and sequence initiators. Further provided herein are compositions and methods of treating conditions related to coronary disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.