Nucleic acid binding domains and methods of use thereof
US12264181B2 · kind B2 · utility
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31References
13Claims
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Key dates
| Filing date | Jun 26, 2019 |
| Grant date | Apr 1, 2025 |
| Priority date | — |
| Expiry date | Apr 21, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are polypeptides, compositions comprising the polypeptides and methods for genome editing and gene regulation (e.g., activation and/or repression) using the polypeptides or the compositions comprising the polypeptides, such as, DNA binding domains derived from the genus of Ralstonia. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a TALE protein, such as, a Xanthomonas TALE protein. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a DNA binding protein derived from bacteria of the genus Ralstonia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.