Tandem diabody for CD16A-directed NK-cell engagement

US12264198B2 · kind B2 · utility

Assignee

• AFFIMED GMBH · DE

Inventors

• Thorsten Ross · Edingen-Neckarhausen, DE
• Ivica Fucek · Hattersheim, DE
• Kristina Ellwanger · Heidelberg, DE
• Michael Weichel · Bischofsheim, DE
• Uwe Reusch · Maikammer, DE
• Stefan Knackmuss · Plankstadt, DE
• Erich Rajkovic · Schriesheim, DE
• Martin Treder · Heidelberg, DE

Key dates

• Filing date: Oct 26, 2021
• Grant date: Apr 1, 2025
• Expiry date: Jul 29, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a multispecific antigen-binding molecule specifically binding to CD16A and consisting of two polypeptide chains, wherein each polypeptide chain comprises at least four variable domains from the N-terminus to the C-terminus in the order: VH_BCMA-VL_CD16A-VH_CD16A-VL_BCM.