Devices and methods for isolating a migratory cell population

US12264305B2 · kind B2 · utility

Assignees

• The Board of Regents of the University of Texas System · US
• The Board of Regents of the University of Oklahoma · US

Inventors

• Young Tae Kim · Incheon, KR
• Loan Bui · Arlington, US
• James Battiste · Edmond, US
• Xue Qing Cai · Fremont, US
• Michael Edward Sughrue · Sydney, AU

Key dates

• Filing date: Sep 18, 2019
• Grant date: Apr 1, 2025
• Expiry date: Aug 4, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N5/0693
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method and device for isolating a migratory cell population from a mixed population of migratory cells and non-migratory cells is described herein. The method comprises placing the mixed population of migratory cells and non-migratory cells in contact with a device having one or more microchannels; and isolating the migratory cell population within the microchannels following an incubation period, wherein the one or more microchannels have an average size in a proliferation direction of the migratory cells that is less than a minimum proliferation space of the migratory cells along the proliferation direction.