Eutectic form A of Elagolix and pyrimethamine, preparation method therefor and use thereof
US12268689B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 2022 |
| Grant date | Apr 8, 2025 |
| Priority date | — |
| Expiry date | Jan 20, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are eutectic form A of Elagolix and pyrimethamine, a preparation method therefor and a use thereof. Using Cu-Kα radiation, eutectic form A has characteristic peaks represented by a 2θ degree at 8.1±0.2°, 12.2±0.2°, 13.3±0.2° and 21.1±0.2° in an X-ray powder diffraction. Eutectic form A has a high purity, a good light radiation stability, a high temperature stability, a high humidity stability and an accelerated stability, is easy to store, and has a slow moisture absorption under the condition of relatively low humidity, wherein the weight gain of eutectic form A by moisture absorption is not more than 1.08% when the relative humidity increases from 0 to 60% RH. Production conditions for eutectic form A are easy to control, same has a simple preparation process and a stable quality, and is easy to industrially produce on a large-scale.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.