Material and method for treating internal cavities

US12268745B2 · kind B2 · utility

Assignee

• UroGen Pharma Ltd. · IL

Inventors

• Asher Holzer · Haifa, IL
• Dorit Daniel · Raanana, IL
• Michael Mullerad · Nes Ziona, IL
• Jaime De La Zerda · Haifa, IL
• Uri Shpolansky · Pardes Hana-Karkur, IL
• Nadav Malchi · Pardes Hana-Karkur, IL
• Yosh Dollberg · Raanana, IL
• Dor Tal · Hadera, IL
• Yossi Yavin · Ashkelon, IL

Key dates

• Filing date: Apr 3, 2024
• Grant date: Apr 8, 2025
• Expiry date: Apr 3, 2044

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A hydrophilic biocompatible sustained-release material is disclosed. The material comprises amounts of an ethylene oxide/propylene oxide block copolymer, HPMC, and water, effective to produce a composition of sufficiently low viscosity at room temperature to be injectable into an internal body cavity via a tube inserted within a urinary catheter. At body temperature, the material exhibits a much higher viscosity and will stably adhere to the internal surface of a body cavity. As the material dissolves, a therapeutic agent incorporated therein is slowly released to the body cavity, while the material itself is excreted from the body.