Process for the preparation of a cyclic dinucleotide

US12269840B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Michael Schmidt · Weiterstadt, DE
• Bin Zheng · Kendall Park, US
• Benjamin M. Cohen · Cranford, US
• Amanda J. Rogers · Asbury, US
• Changxia Yuan · Pequest, US
• Jason J. Zhu · East Brunswick Township, US
• Chao Hang · Monmouth Junction, US
• Daniel S. Treitler · Cranford, US
• Adam Joseph Freitag · Hopewell, US
• Geoffrey Eugene Purdum · Freehold, US
• Miao Yu · Malvern, US
• Melda Sezen Edmonds · Princeton, US
• Siwei Guo · Atlanta, US

Key dates

• Filing date: Dec 3, 2019
• Grant date: Apr 8, 2025
• Expiry date: Nov 30, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.