Production method for oligonucleotides
US12269841B2 · kind B2 · utility
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Key dates
| Filing date | Aug 12, 2021 |
| Grant date | Apr 8, 2025 |
| Priority date | — |
| Expiry date | Dec 10, 2043 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for producing an oligonucleotide, including a step of removing a temporary protecting group of a 5′-hydroxyl group by adding an acid to a protected oligonucleotide having a phosphorothioate (PS), phosphate (PO) or H-phosphonate moiety, and deacylating a by-product having an acylated 5′-hydroxyl group by solvolysis can complete a condensation reaction to improve a condensation yield, and can markedly reduce impurities such as single base deletion form (N-1mer) and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.