Compositions and methods comprising engineered chimeric antigen receptor and modulator of CAR
US12269860B2 · kind B2 · utility
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Key dates
| Filing date | May 17, 2022 |
| Grant date | Apr 8, 2025 |
| Priority date | — |
| Expiry date | Nov 3, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided method for making a cell composition which comprises step of transducing a population of cells with a mixture of at least two viral vectors, wherein at least one vector comprises a nucleic acid sequence which encodes a chimeric antigen receptor (CAR); and wherein at least one vector comprises a nucleic acid encoding an activity modulator which modulates the activity of the CAR, of a cell expressing the CAR, or of a target cell. There is also provided a cell composition made by such a method and its use in the treatment of diseases such as cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.