Artificial cell death polypeptide for chimeric antigen receptor and uses thereof

US12269888B2 · kind B2 · utility

Assignee

• Century Therapeutics, Inc. · US

Inventors

• Michael Naso · Union, US
• Jill Carton · Collegeville, US
• John Wheeler · Spring House, US
• Luis Borges · Seattle, US
• Mark Wallet · Philadelphia, US
• Barry Morse · Havertown, US
• Hillary Quinn · Philadelphia, US
• Liam Campion · Philadelphia, US
• Buddha Gurung · Philadelphia, US
• Heidi Jessup · Chicago, US
• Kenneth Brasel · Philadelphia, US
• Lucas Thompson · Philadelphia, US

Key dates

• Filing date: Mar 30, 2023
• Grant date: Apr 8, 2025
• Expiry date: Mar 30, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are polynucleotides encoding inactivated cell surface receptors. Also provided are genetically engineered induced pluripotent stem cells (iPSCs) and derivative cells thereof expressing a chimeric antigen receptor (CAR) and methods of using the same. Also provided are compositions, polypeptides, vectors, and methods of manufacturing.