Compositions and methods for targeting, editing, or modifying genes

US12270043B2 · kind B2 · utility

Assignee

• Celyntra Therapeutics SA · BE

Inventors

• Andrea BARGHETTI · Copenhagen, DK
• Roland BAUMGARTNER · Birkenfeld, DE
• Tanya WARNECKE · Boulder, US
• Kurt Marshall · Boulder, US
• John A. Schiel · Littleton, US
• Alyssa Carlson · Westminster, US

Key dates

• Filing date: Mar 23, 2023
• Grant date: Apr 8, 2025
• Expiry date: Mar 23, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/80
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are nucleic acids useful as guide nucleic acids (gNAs), e.g., guide ribonucleic acids (gRNAs), in a CRISPR system wherein the guide nucleic acids contain one or more modifications to one or more nucleotides, use of such guide nucleic acids in modifying cells, and other uses wherein CRISPR Cas proteins are utilized.