Human T cell derived from T cell-derived induced pluripotent stem cell and methods of making and using

US12270050B2 · kind B2 · utility

Assignee

• Regents of the University of Minnesota · US

Inventors

• Bruce R. Blazar · Golden Valley, US
• Dharmeshkumar PATEL · Falcon Heights, US
• Beau Webber · Coon Rapids, US
• Jakub Tolar · Minneapolis, US

Key dates

• Filing date: Dec 8, 2016
• Grant date: Apr 8, 2025
• Expiry date: Dec 20, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Induced pluripotent stem cells (iPSCs) derived from a T cell of a T cell subset. T cells derived from iPSCs derived from a T cell. Methods of deriving iPSCs from a T cell. Methods of deriving T cells from iPSCs including deriving a T cell of a T cell subset from an iPSC. Methods of engineering chimeric antigen receptor (CAR)-expressing or T cell receptor (TCR)-expressing iPSC. Methods of administering T cells derived using the methods disclosed. Induced pluripotent stem cell lines derived from T cells, methods of deriving induced pluripotent stem cell lines, and methods of deriving T cells from induced pluripotent stem cell lines.