Genetically modified rat models for severe combined immunodeficiency (SCID)
US12274247B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Jun 1, 2021 |
| Grant date | Apr 15, 2025 |
| Priority date | — |
| Expiry date | Feb 15, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8536
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.