Substituted alkylphenols as HCN1 antagonists
US12274679B2 · kind B2 · utility
0Cited by
7References
10Claims
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Assignee
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Key dates
| Filing date | Apr 26, 2023 |
| Grant date | Apr 15, 2025 |
| Priority date | — |
| Expiry date | Jun 22, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.