Patent · US Active

Affibody proteins specific for B7-H3 (CD276)

US12274759B2 · kind B2 · utility

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26Claims

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Assignee

Regents of the University of Minnesota · US

Inventors

Lotfi Abou-Elkacem · Houston, US
Juergen Karl Willmann · Stanford, US
Benjamin Hackel · Edina, US
Lawrence Stern · Duarte, US
Patrick Samuel Lown · Minneapolis, US
Amelie Margarete Marianne Lutz · Stanford, US
Rakesh Kumar Bam · Menlo Park, US

Key dates

Filing date	Aug 22, 2019
Grant date	Apr 15, 2025
Priority date	—
Expiry date	Jan 13, 2042

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/52
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity. The affibodies can be conjugated to contrast agents, including without limitation microbubbles for contrast-enhanced ultrasound imaging

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.