Microbubble dispersion system stabilized with polydopamine nanoparticles for highly-efficient intravenous oxygen supply and method for preparing the same
US12274783B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 14, 2021 |
| Grant date | Apr 15, 2025 |
| Priority date | — |
| Expiry date | Feb 15, 2044 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y40/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application discloses a microbubble dispersion system stabilized with polydopamine nanoparticles for highly-efficient intravenous oxygen supply and a method for preparing the same. The method includes: dissolving dopamine, chitosan quaternary ammonium salt and amino-rich polymer in water, adjusting the pH to be alkaline, and then introducing oxygen into the solution; under the strong shear force of a homogenizer, oxygen oxidizing dopamine, and the obtained polydopamine nanoparticles adhering to the interface of oxygen microbubbles during polymerization, forming a compact shell layer of polydopamine particles; finally, adding glutaraldehyde to solidify the shell layer of polydopamine particles adhered to the interface of microbubbles, and obtaining oxygen microbubbles stably dispersed in water by filtration, washing and redispersion. The oxygen microbubbles stabilized with polydopamine nanoparticles have excellent biocompatibility, can realize rapid and efficient delivery of oxygen, and thus have an important application value in the field of highly-efficient intravenous oxygen supply.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.