Pleuromutilin onium salt derivative containing a 3H-imidazo[4,5-c]pyridine side chain, and a preparation method and application thereof

US12275734B1 · kind B1 · utility

Assignee

• SHAANXI UNIVERSITY OF SCIENCE AND TECHNOLOGY · CN

Inventors

• Chengyuan Liang · Xi'an, CN
• Yanzi Wang · Tuji, CN
• Kairui Kang · Xi'an, CN
• Bingxing Zhang · Xi'an, CN
• Wen Wang · Xi'an, CN
• Yunfei Zhang · Aurora, CA
• Mengzhou Wang · Xi'an, CN

Key dates

• Filing date: Nov 18, 2024
• Grant date: Apr 15, 2025
• Expiry date: Nov 18, 2044

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed. The 3H-imidazo[4,5-C]pyridine pleuromutilin onium salt derivatives exhibit good water solubility and excellent activity against resistant mycoplasma, in vivo and in vitro antibacterial activity, and are of great value in the development of anti-resistant bacteria drugs and have good medical application prospects.