Microbial contamination control in bioprocessing
US12275927B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | May 5, 2022 |
| Grant date | Apr 15, 2025 |
| Priority date | — |
| Expiry date | Jul 3, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y113/11049
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Biomanufacturing hygiene control in batch and fed-batch bioreactors is provided using a bioreactor employing a chlorite/Cld system, wherein the bioreactor comprises an engineered cultured cell expressing a recombinant cytoplasmic chlorite dismutase (cCld) sufficient to increase chlorite resistance of the cell, and chlorite sufficient to substantially inhibit growth of one or more contaminating microorganisms in the bioreactor yet not substantially inhibit growth of the cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.