Gapped and tunable repeat units for use in genome editing and gene regulation compositions
US12275935B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Jun 26, 2019 |
| Grant date | Apr 15, 2025 |
| Priority date | — |
| Expiry date | Aug 19, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/50
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are DNA binding domains comprising a plurality of repeat units, wherein each repeat unit is expanded or contracted in length. Also provided herein are DNA binding domains comprising a plurality of repeat units, wherein each repeat unit is separated from a neighboring repeat unit by a linker. In certain aspects, the linker includes a recognition site. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a TALE protein. The TALE protein may be a Xanthomonas TALE protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.