Methods for screening and identifying agents that inhibit or modulate the nuclear egress complex of herpesviruses

US12276665B2 · kind B2 · utility

Assignee

• AICURIS ANTI-INFECTIVE CURES AG · DE

Inventors

• Manfred Marschall · Nuremberg, DE
• Yves Muller · Panketal, DE
• Heinrich Sticht · Fürth, DE
• Jutta Eichler · Berlin, DE

Key dates

• Filing date: Jul 19, 2019
• Grant date: Apr 15, 2025
• Expiry date: May 20, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/05
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention generally provides for a novel NEC-targeted strategy for the development of antiherpesviral drugs as well as for a novel antiviral strategy targeting the viral-cellular nuclear egress complex (NEC) for a small molecule-based therapy or prophylaxis to control infections with human cytomegalovirus or other pathogenic viruses of the group of the Herpesviridae. Methods for screening agents/compounds/small molecules modulating/inhibiting the nuclear egress complex of Herpesviridae are provided as well. Specifically novel drug targets of the viral nuclear egress complex of viruses of the Herpesviridae are provided.