Super-resolution imaging system and method, and nucleic acid sequencing imaging system and method

US12276809B2 · kind B2 · utility

Assignee

• BGI SHENZHEN · CN

Inventors

• Jielei Ni · Lo Wu, CN
• Ming Ni · Laguna Niguel, US
• Fan Zhou · Shanghai, CN
• Zeyu Su · Mountain View, US
• Ke Ji · Lo Wu, CN
• Dong Wei · East Lansing, US
• Mengzhe Shen · Lo Wu, CN
• Yuanqing Liang · Lo Wu, CN
• Mei Li · Beijing, CN
• Xun Xu · Shanghai, CN

Key dates

• Filing date: Mar 9, 2020
• Grant date: Apr 15, 2025
• Expiry date: Jun 12, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G02B2207/113
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed are a super-resolution imaging system (1, 41, 51), a super-resolution imaging method, a biological sample identification system (4, 61) and method, a nucleic acid sequencing imaging system (5) and method, and a nucleic acid identification system (6) and method. The super-resolution imaging system (1, 41, 51) includes an illumination system (A) and an imaging system (B). The illumination system (A) outputs excitation light to irradiate a biological sample to generate excited light, and the imaging system (B) collects and records the excited light to generate an excited light image. The illumination system (A) includes an excitation light source (10, 10a) and a structured light generation and modulation device (11, 11a). The excitation light source (10, 10a) outputs the excitation light, and the structured light generation and modulation device (11, 11a) modulates the excitation light into structured light to irradiate the biological sample to generate the excited light.