Magnetic delivery system and hydrogel fixative for therapeutic cells
US12280112B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Oct 18, 2019 |
| Grant date | Apr 22, 2025 |
| Priority date | — |
| Expiry date | Jul 4, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2205/0288
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.