Colonic microbiota responsive polymer and its preparation method and use
US12280154B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 26, 2023 |
| Grant date | Apr 22, 2025 |
| Priority date | — |
| Expiry date | Sep 26, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L5/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a colonic microbiota responsive polymer characterized in that it is prepared by the polymerization of a response monomer and a linking monomer, wherein the response monomer is a cellobiose with a β-(1,4)-glucoside bond or/and a lactose with a β-galactoside bond; the linking monomer is a monomer that reacts with the hydroxyl group of the response monomer to form an ester or ether directly or by a crosslinking agent. The invention also provides a method for preparation of a colonic microbiota responsive polymer, a degradable film based on the polymer and a preparation method thereof. By means of the characteristics that β-(1,4)-glucoside bond provided by cellobiose or/and β-galactoside bond provided by lactose monomer unit in the polymer can specifically respond to the high abundance of microbiotas (β-glucosidase or/and β-galactosidase) in the colon to specifically degrade in the colon, a colon-targeted delivery system for diagnosis and treatment of colon diseases is constructed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.