Functionalization of plant tissues for human cell expansion

US12280177B2 · kind B2 · utility

Assignees

• Wisconsin Alumni Research Foundation · US
• Arkansas State University—Jonesboro · US
• Worcester Polytechnic Institute · US

Inventors

• William L. Murphy · Waunakee, US
• Gianluca Fontana · Town of Waukesha, US
• Joshua Gershlak · Melrose, US
• Glenn Gaudette · Holden, US
• Pam Weathers · Stow, US
• Tanja Dominko · Worcester, US
• Marsha Rolle · Worcester, US
• Sarah Hernandez · Union City, US
• Carol Cramer · Lake Zurich, US
• Luis Fabircio Medina-Bolivar · Memphis, US
• Bernard Binder · Pleasant Hill, US

Key dates

• Filing date: Jul 29, 2021
• Grant date: Apr 22, 2025
• Expiry date: Jul 16, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2535/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.