Quinoline derivatives, processes for their preparation and uses thereof for the treatment of cancer

US12281079B2 · kind B2 · utility

Assignee

• Lead Discovery Center GmbH · DE

Inventors

• Raffaella Di Lucrezia · Wuppertal, DE
• Tim Bergbrede · Dortmund, DE
• Peter Nussbaumer · Schwanenstadt, AT
• Peter Schröder · Dortmund, DE

Key dates

• Filing date: Mar 19, 2020
• Grant date: Apr 22, 2025
• Expiry date: May 7, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of the general formula (I): (I), wherein V, W, M, R, R and Y have the designations cited below, or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof, and to processes for the preparation of compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof. The invention also relates to compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof for use as a medicament. Further, the invention relates to compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof for use in the treatment of cancer. Moreover, the invention relates to compounds of the general formula (I) or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof for treating cancer in simultaneous, alternating or subsequent combination with another cancer therapy.