Heterodimer molecule based on CH3 domain, and preparation method and use thereof
US12281177B2 · kind B2 · utility
Assignees
Inventor
Key dates
| Filing date | Oct 7, 2021 |
| Grant date | Apr 22, 2025 |
| Priority date | — |
| Expiry date | Jul 4, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure is directed to a heterodimer molecule, comprising a first polypeptide chain and a second polypeptide chain, and the first polypeptide chain comprises a first CH3 domain of an antibody heavy chain constant region, the second polypeptide chain comprises a second CH3 domain of an antibody heavy chain constant region. Comparing to a corresponding wild-type CH3 domain of a human antibody heavy chain constant region, the first CH3 domain and the second CH3 domain comprise specific substitution mutations combination, for example, for the first CH3 domain: T366W+F405K, and for the second CH3 domain: T366S+L368A+Y407V+K409A.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.