Method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate
US12281348B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2021 |
| Grant date | Apr 22, 2025 |
| Priority date | — |
| Expiry date | Jul 6, 2043 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00889
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This application relates to organic synthesis, and more particularly to a method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate using a micro-reaction system. This application performs an enzymatic asymmetric reduction of a substrate solution containing halogenated acetoacetate and a biocatalyst solution in the micro-reaction system composed of a micro-mixer, a micro-channel reactor, and a pH regulator to obtain the (R)-4-halo-3-hydroxy-butyrate. Compared to the prior art, the reaction time of the method is only a few minutes, the yield of the product (R)-4-halo-3-hydroxy-butyrate is greater than 95%, the reaction process is continuous, the degree of automation is high, the efficiency is high, and the process is simple to operate and easy to be used in industrialized production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.