Patent · US Active

Ultrasensitive molecular detection via hybridization chain reaction

US12281352B2 · kind B2 · utility

0Cited by

16References

17Claims

0Family size

Assignees

CALIFORNIA INSTITUTE OF TECHNOLOGY · US
Molecular Instruments, Inc. · US

Inventors

Harry M T Choi · Pasadena, US
Chun-Hao Chen · Arcadia, US
Mike C. Liu · Los Angeles, US
Aneesh Acharya · Altadena, US
Niles A. Pierce · Pasadena, US

Key dates

Filing date	Apr 15, 2024
Grant date	Apr 22, 2025
Priority date	—
Expiry date	Apr 15, 2044

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6841
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.