Trim proteins and galectins cooperate and codirect autophagy and are useful in the treatment of autophagy related diseases
US12285470B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 31, 2017 |
| Grant date | Apr 29, 2025 |
| Priority date | — |
| Expiry date | Jan 17, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tie present invention relates to compositions and methods of influencing autophagy by modulating TRIM (tripartite motif containing) proteins, especially TRIM 8, TRIM: 10, TRIM 16, TRIM 19 and/or TRIM 51 (preferably TRIM 16} and galectins, especially galectins 3 m order to influence autophagy and treat a number of disease states and/or conditions which are mediated and/or influenced by autophagy, including inflammatory disease states and/or conditions, including a microbial infection such as a Mycobacterium infection, among numerous others, an inflammatory disorder, a lysosomal, storage disorder, an immune disorder, a neurodegenerative disorder and a cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.