Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers
US12285491B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Jun 8, 2022 |
| Grant date | Apr 29, 2025 |
| Priority date | — |
| Expiry date | Jul 1, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.