Regeneration of vital tooth pulp

US12285545B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Juan M. Taboas · Ann Arbor, US
• Herbert L. Ray · Leechburg, US
• Jingming Chen · Pittsburgh, US
• Patrick E. Donnelly · Lawrenceville, US
• Tyler Swenson · Pittsburgh, US

Key dates

• Filing date: Mar 20, 2019
• Grant date: Apr 29, 2025
• Expiry date: Mar 20, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of regenerating vital tooth tissue in situ after endodontic therapy include introducing a hydrogel scaffold into a root canal of a tooth in a patient after native pulp has been removed from the root canal. The hydrogel scaffold may comprise a sponge scaffold, and can be acellular. The hydrogel scaffold can contain chemotactic, angiogenic, neurogenic, and/or immunomodulatory biofactors that cause infiltration of endogenous cells from the patient into the root canal. Alternatively, such biofactors/drugs can be administered to the patient separately from the hydrogel scaffold. The hydrogel scaffold can fill the periapical space of an abscessed root.