Fabrication and irradiation of a radioactive isotope skin patch

US12285627B2 · kind B2 · utility

Assignees

• Colorado School of Mines · US
• The Regents of the University of Colorado, a Body Corporate · US

Inventors

• Frédéric Sarazin · Lakewood, US
• Jeramy D. Zimmerman · Golden, US
• Rachel Morneau · Los Alamos, US
• Martin Ritter · Rueil-Malmaison, FR
• David C. Westerly · Madison, US
• Quentin Diot · Aurora, US

Key dates

• Filing date: Oct 18, 2019
• Grant date: Apr 29, 2025
• Expiry date: Oct 18, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2005/1096
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel treatment method is disclosed, wherein a patch configured to be placed on a patient's skin is activated, before placement, to deliver localized radiotherapy to a diseased area of the skin. The disclosed devices and methods minimize or prevent collateral damage to the neighboring tissues. In most cases, the disclosed devices and methods include coating a contoured, solid, flexible or conformal substrate with one or more lanthanide elements and then activating (e.g. neutron irradiation) the elements such that its resulting radioisotope emits beta-particles into the diseased skin surface when applied to the patient's skin. Novel processes are described for fabricating and irradiating the lanthanide-based skin patch, for example a holmium-based skin patch.