Patent · US Active

Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains

US12286465B2 · kind B2 · utility

0Cited by

3References

12Claims

0Family size

Assignee

MILTENYI BIOTEC B.V. & CO. KG · DE

Inventors

Rita Pfeifer · Cologne, DE
Daniel Schäfer · Greenville, US
Ian Johnston · Rösrath, DE

Key dates

Filing date	May 27, 2021
Grant date	Apr 29, 2025
Priority date	—
Expiry date	Feb 29, 2044

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are chimeric antigen receptors (CARs) that include a) an antigen binding domain specific for an antigen, b) a spacer, c) a transmembrane domain, and d) an intracellular signaling domain, wherein the spacer consists of 1, 2 or 3 C2-set Ig-like domain(s) e.g., C2-set Ig-like domains of the sialic acid binding Ig-like lectin (Siglec) family. Also provided herein are compositions including a) an immune cell expressing a CAR, wherein the CAR is specific for a tag and b) a tagged polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.